Pathophysiology - 8th Edition (2023)

Pathophysiology - 8th Edition (1)

The Biologic Basis for Disease in Adults and Children

8th Edition - December 27, 2016

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  • Authors: Kathryn McCance, Sue Huether
  • Paperback ISBN: 9780323639507
  • eBook ISBN: 9780323413206

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Description

Learn the what, how, and why of pathophysiology! With easy-to-read, in-depth descriptions of disease, disease etiology, and disease processes, Pathophysiology: The Biologic Basis for Disease in Adults and Children, 8th Edition helps you understand the most important and most complex pathophysiology concepts. This updated text includes more than 1,300 full-color illustrations and photographs to make it easier to identify normal anatomy and physiology, as well as alterations of function. This edition includes a NEW chapter on obesity and nutritional disorders, along with expanded coverage of rare diseases and epigenetics. It’s the most comprehensive and authoritative pathophysiology text available!

Key Features

  • The most comprehensive and authoritative pathophysiology text on the market
  • provides unparalleled coverage of Pathophysiology content.
  • Over 1,300 full-color illustrations and photographs depict the clinical manifestations of disease and disease processes — more than in any other pathophysiology text.
  • Consistent presentation of diseases includes pathophysiology, clinical manifestations, and evaluation and treatment.
  • Lifespan content includes ten separate pediatric chapters and special sections with aging and pediatrics content.
  • Outstanding authors Kathryn McCance and Sue Huether have extensive backgrounds as researchers and instructors, and utilize expert contributors, consultants, and reviewers in developing this edition.
  • Algorithms and flowcharts of diseases and disorders make it easy for you to follow the sequential progression of disease processes.
  • Additional What’s New boxes highlight the most current research and clinical development.
  • Nutrition and Disease boxes explain the link between concepts of health promotion and disease.
  • Chapter summary reviews provide concise synopses of the main points of each chapter.

Table of Contents

  • Cover image
  • Title Page
  • Table of Contents
  • What's New?
  • About the Cover Image
  • Copyright
  • Contributors
  • Reviewers
  • Preface
  • Organization and Content: What's New in the Eighth Edition
  • Features to Promote Learning
  • Art Program
  • Ancillaries
  • Acknowledgments
  • Introduction to Pathophysiology
  • References
  • Part One Central Concepts of Pathophysiology: Cells and Tissues
  • Unit I The Cell
  • 1 Cellular Biology
  • Prokaryotes and Eukaryotes
  • Cellular Functions
  • Structure and Function of Cellular Components
  • Cell-to-Cell Adhesions
  • Cellular Communication and Signal Transduction
  • Cellular Metabolism
  • Membrane Transport: Cellular Intake and Output
  • Cellular Reproduction: the Cell Cycle
  • Tissues
  • Summary Review
  • Key Terms
  • References
  • 2 Altered Cellular and Tissue Biology
  • Cellular Adaptation
  • Cellular Injury
  • Manifestations of Cellular Injury
  • Cellular Death
  • Aging and Altered Cellular and Tissue Biology
  • Somatic Death
  • Summary Review
  • Key Terms
  • References
  • 3 The Cellular Environment
  • Distribution of Body Fluids
  • Aging and Distribution of Body Fluids
  • Alterations in Water Movement
  • Sodium, Chloride, and Water Balance
  • Alterations in Sodium, Water, and Chloride Balance
  • Alterations in Potassium, Calcium, Phosphate, and Magnesium Balance
  • Acid-Base Balance
  • Summary Review
  • Key Terms
  • References
  • Unit II Genes, Gene-Environment Interaction, and Epigenetics
  • 4 Genes and Genetic Diseases
  • DNA, RNA, and Proteins: Heredity at the Molecular Level
  • Chromosomes
  • Elements of Formal Genetics
  • Transmission of Genetic Diseases
  • Linkage Analysis and Gene Identification
  • Summary Review
  • Key Terms
  • References
  • 5 Genes, Environment-Lifestyle, and Common Diseases
  • Factors Influencing Incidence of Disease in Populations
  • Principles of Multifactorial Inheritance
  • Nature and Nurture: Disentangling the Effects of Genes and Environment
  • Genetics of Common Diseases
  • Summary Review
  • Key Terms
  • References
  • 6 Epigenetics and Disease
  • Overview of Epigenetic Mechanisms
  • Epigenetics and Human Development
  • Genomic Imprinting
  • Epigenetics in Cognitive Development and Mental Health
  • Exploring the Possible Multigenerational Persistence of Epigenetic States That Arise in Response to Environmental Factors
  • Epigenetic Change Over the Life Span
  • Molecular and Computational Tools for Exploring Epigenetic States
  • Epigenetics and Cancer
  • Emerging Strategies for the Treatment of Epigenetic Disease
  • Future Directions
  • Summary Review
  • Key Terms
  • References
  • Unit III Mechanisms of Self-Defense
  • 7 Innate Immunity
  • Human Defense Mechanisms
  • First Line of Defense: Physical, Mechanical, and Biochemical Barriers and Normal Microbiome
  • Second Line of Defense: Inflammation
  • Local Manifestations of Inflammation
  • Systemic Manifestations of Acute Inflammation
  • Chronic Inflammation
  • Wound Healing
  • Pediatrics: Innate Immunity in the Newborn Child
  • Aging: Innate Immunity in the Older Adult Population
  • Summary Review
  • Key Terms
  • References
  • 8 Adaptive Immunity
  • General Characteristics of Adaptive Immunity
  • Recognition and Response
  • Generation of Clonal Diversity
  • Induction of an Immune Response: Clonal Selection
  • Effector Mechanisms
  • Fetal and Neonatal Immune Function
  • Aging and Immune Function
  • Summary Review
  • Key Terms
  • References
  • 9 Alterations in Immunity and Inflammation
  • Hypersensitivity: Allergy, Autoimmunity, and Alloimmunity
  • References:
  • Deficiencies in Immunity
  • Summary Review
  • Key Terms
  • References
  • 10 Infection
  • Emerging Infections
  • References
  • Microorganisms and Humans: a Dynamic Relationship
  • Microorganisms and Infections
  • References
  • References
  • References
  • References
  • Human Immunodeficiency Virus and Acquired Immunodeficiency Syndrome
  • Countermeasures Against Pathogens
  • References
  • Summary Review
  • Key Terms
  • References
  • 11 Stress and Disease
  • Historical Background and General Concepts
  • Concepts of Stress, Homeostasis, and Allostasis
  • Stress Response
  • Stress, Illness, and Coping
  • Aging and Stress: Stress-Age Syndrome
  • Summary Review
  • Key Terms
  • References
  • Unit IV Cellular Proliferation: Cancer
  • 12 Cancer Biology
  • Cancer Characteristics and Terminology
  • The Biology of Cancer Cells
  • Clinical Manifestations of Cancer
  • Diagnosis and Staging of Cancer
  • Treatment of Cancer
  • Targeted Disruption of Cancer
  • Summary Review
  • Key Terms
  • References
  • 13 Cancer Epidemiology
  • Genetics, Epigenetics, and Tissue
  • Incidence and Mortality Trends
  • In Utero and Early Life Conditions
  • Environmental-Lifestyle Factors
  • Chemicals and Occupational Hazards as Carcinogens
  • Summary Review
  • Key Terms
  • References
  • 14 Cancer in Children
  • Incidence and Types of Cancer
  • Etiology
  • Prognosis
  • Summary Review
  • Key Terms
  • References
  • Part Two Pathophysiologic Alterations: Organs and Systems
  • Unit V Pathophysiologic Alterations: Organs and Systems
  • 15 Structure and Function of the Neurologic System
  • Overview and Organization of the Nervous System
  • Cells of the Nervous System
  • Nerve Impulse
  • Central Nervous System
  • Peripheral Nervous System
  • Autonomic Nervous System
  • Aging and the Nervous System
  • Tests of Nervous System Structure and Function
  • Summary Review
  • Key Terms
  • References
  • 16 Pain, Temperature Regulation, Sleep, and Sensory Function
  • Pain
  • Pediatrics and Perception of Pain
  • Aging and Perception of Pain
  • Temperature Regulation
  • Pediatrics and Temperature Regulation
  • Aging and Temperature Regulation
  • Sleep
  • Pediatrics and Sleep Patterns
  • Aging and Sleep Patterns
  • Somatosensory Function and the Special Senses
  • Aging and Vision
  • Aging and Hearing
  • Aging and Olfaction and Taste
  • Summary Review
  • Key Terms
  • References
  • 17 Alterations in Cognitive Systems, Cerebral Hemodynamics, and Motor Function
  • Alterations in Cognitive Systems
  • Alterations in Cerebral Hemodynamics
  • Alterations in Neuromotor Function
  • Summary Review
  • Key Terms
  • References
  • 18 Disorders of the Central and Peripheral Nervous Systems and the Neuromuscular Junction
  • Central Nervous System Disorders
  • Peripheral Nervous System and Neuromuscular Junction Disorders
  • Tumors of the Central Nervous System
  • Summary Review
  • Key Terms
  • References
  • 19 Neurobiology of Schizophrenia, Mood Disorders, Anxiety Disorders, and Obsessive-Compulsive Disorder
  • Schizophrenia
  • Mood Disorders: Depression and Bipolar Disorder
  • Anxiety Disorders
  • Obsessive-Compulsive Disorder
  • Summary Review
  • Key Terms
  • References
  • 20 Alterations of Neurologic Function in Children
  • Development of the Nervous System in Children
  • Structural Malformations
  • Alterations in Function: Encephalopathies
  • Cerebrovascular Disease in Children
  • Epilepsy and Seizure Disorders in Children
  • Childhood Tumors
  • Summary Review
  • Key Terms
  • References
  • Unit VI The Endocrine System
  • 21 Mechanisms of Hormonal Regulation
  • Mechanisms of Hormonal Regulation
  • Structure and Function of the Endocrine Glands
  • Aging and the Endocrine System
  • Summary Review
  • Key Terms
  • References
  • 22 Alterations of Hormonal Regulation
  • Mechanisms of Hormonal Alterations
  • Alterations of the Hypothalamic-Pituitary System
  • Alterations of Thyroid Function
  • Alterations of Parathyroid Function
  • Dysfunction of the Endocrine Pancreas: Diabetes Mellitus
  • Alterations of Adrenal Function
  • Summary Review
  • Key Terms
  • References
  • 23 Obesity and Disorders of Nutrition
  • Adipose Tissue
  • Obesity
  • Anorexia Nervosa, Bulimia Nervosa, and Binge Eating Disorder
  • Starvation
  • Anorexia of Aging
  • Summary Review
  • Key Terms
  • References
  • Unit VII The Reproductive Systems
  • 24 Structure and Function of the Reproductive Systems
  • Development of the Reproductive Systems
  • The Female Reproductive System
  • Structure and Function of the Breast
  • The Male Reproductive System
  • Tests of Reproductive Function
  • Aging and Reproductive Function
  • Summary Review
  • Key Terms
  • References
  • 25 Alterations of the Female Reproductive System
  • Abnormalities of Reproductive Tract Development
  • Alterations of Sexual Maturation
  • Disorders of the Female Reproductive System
  • Disorders of the Female Breast
  • Summary Review
  • Key Terms
  • References
  • 26 Alterations of the Male Reproductive System
  • Alterations of Sexual Maturation
  • Disorders of the Male Reproductive System
  • Disorders of the Male Breast
  • Summary Review
  • Key Terms
  • References
  • 27 Sexually Transmitted Infections
  • Sexually Transmitted Urogenital Infections
  • Sexually Transmitted Infections of Other Body Systems
  • Summary Review
  • Key Terms
  • References
  • Unit VIII The Hematologic System
  • 28 Structure and Function of the Hematologic System
  • Components of the Hematologic System
  • Development of Blood Cells
  • References
  • Mechanisms of Hemostasis
  • Clinical Evaluation of the Hematologic System
  • Pediatrics and the Hematologic System
  • Aging and the Hematologic System
  • Summary Review
  • Key Terms
  • References
  • 29 Alterations of Erythrocyte, Platelet, and Hemostatic Function
  • Anemia
  • Myeloproliferative Red Blood Cell Disorders
  • Alterations of Platelets and Coagulation
  • Summary Review
  • Key Terms
  • References
  • 30 Alterations of Leukocyte and Lymphoid Function
  • Alterations of Leukocyte Function
  • Alterations of Lymphoid Function
  • Alterations of Splenic Function
  • Summary Review
  • Key Terms
  • References
  • 31 Alterations of Hematologic Function in Children
  • Fetal and Neonatal Hematopoiesis
  • Postnatal Changes in the Blood
  • Disorders of Erythrocytes
  • Disorders of Coagulation and Platelets
  • Neoplastic Disorders
  • Summary Review
  • Key Terms
  • References
  • Unit IX The Cardiovascular and Lymphatic Systems
  • 32 Structure and Function of the Cardiovascular and Lymphatic Systems
  • Circulatory System
  • The Heart
  • The Systemic Circulation
  • Lymphatic System
  • Tests of Cardiovascular Function
  • Aging and the Cardiovascular System
  • Summary Review
  • Key Terms
  • References
  • 33 Alterations of Cardiovascular Function
  • Diseases of the Veins
  • Diseases of the Arteries
  • Disorders of the Heart Wall
  • Manifestations of Heart Disease
  • Summary Review
  • Key Terms
  • References
  • 34 Alterations of Cardiovascular Function in Children
  • Development of The Cardiovascular System
  • Congenital Heart Defects
  • Acquired Cardiovascular Disorders
  • Summary Review
  • Key Terms
  • References
  • Unit X The Pulmonary System
  • 35 Structure and Function of the Pulmonary System
  • Structures of the Pulmonary System
  • References
  • Functions of the Pulmonary System
  • Tests of Pulmonary Function
  • Aging and the Pulmonary System
  • Summary Review
  • Key Terms
  • References
  • 36 Alterations of Pulmonary Function
  • Clinical Manifestations of Pulmonary Alterations
  • Disorders of the Chest Wall and Pleura
  • Pulmonary Disorders
  • References
  • Summary Review
  • Key Terms
  • References
  • 37 Alterations of Pulmonary Function in Children
  • Structure and Function
  • Disorders of the Upper Airways
  • Disorders of the Lower Airways
  • Sudden Infant Death Syndrome
  • Summary Review
  • Key Terms
  • References
  • Unit XI The Renal and Urologic Systems
  • 38 Structure and Function of the Renal and Urologic Systems
  • Structures of the Renal System
  • Renal Blood Flow
  • Kidney Function
  • Tests of Renal Function
  • Aging and Renal Function
  • Summary Review
  • Key Terms
  • References
  • 39 Alterations of Renal and Urinary Tract Function
  • Urinary Tract Obstruction
  • Urinary Tract Infection
  • Glomerular Disorders
  • Acute Kidney Injury
  • Chronic Kidney Disease
  • Summary Review
  • Key Terms
  • References
  • 40 Alterations of Renal and Urinary Tract Function in Children
  • Structure and Function of the Urinary System in Children
  • Alterations in Renal and Bladder Function in Children
  • Summary Review
  • Key Terms
  • References
  • Unit XII The Digestive System
  • 41 Structure and Function of the Digestive System
  • The Gastrointestinal Tract
  • Accessory Organs of Digestion
  • Tests of Digestive Function
  • Aging and the Gastrointestinal System
  • Summary Review
  • Key Terms
  • References
  • 42 Alterations of Digestive Function
  • Disorders of the Gastrointestinal Tract
  • Disorders of the Accessory Organs of Digestion
  • Cancer of the Digestive System
  • Summary Review
  • Key Terms
  • References
  • 43 Alterations of Digestive Function in Children
  • Disorders of the Gastrointestinal Tract
  • Disorders of the Liver
  • Summary Review
  • Key Terms
  • References
  • Unit XIII The Musculoskeletal System
  • 44 Structure and Function of the Musculoskeletal System
  • Structure and Function of Bones
  • Structure and Function of Joints
  • Structure and Function of Skeletal Muscles
  • Tests of Musculoskeletal Function
  • Aging and the Musculoskeletal System
  • Summary Review
  • Key Terms
  • References
  • 45 Alterations of Musculoskeletal Function
  • Musculoskeletal Injuries
  • Disorders of Bones
  • Disorders of Joints
  • References
  • Disorders of Skeletal Muscle
  • Summary Review
  • Key Terms
  • References
  • 46 Alterations of Musculoskeletal Function in Children
  • Musculoskeletal Development in Children
  • Musculoskeletal Alterations in Children
  • Nonaccidental Trauma
  • Summary Review
  • Key Terms
  • References
  • Unit XIV The Integumentary System
  • 47 Structure, Function, and Disorders of the Integument
  • Structure and Function of the Skin
  • Aging and Skin Integrity
  • Disorders of the Skin
  • Disorders of the Hair
  • Disorders of the Nail
  • Summary Review
  • Key Terms
  • References
  • 48 Alterations of the Integument in Children
  • Acne Vulgaris
  • Dermatitis
  • Infections of the Skin
  • Insect Bites and Parasites
  • Cutaneous Hemangiomas and Vascular Malformations
  • Other Skin Disorders
  • Summary Review
  • Key Terms
  • References
  • Unit XV Multiple Interacting Systems
  • 49 Shock, Multiple Organ Dysfunction Syndrome, and Burns in Adults
  • Shock
  • Multiple Organ Dysfunction Syndrome
  • Burns
  • Summary Review
  • Key Terms
  • References
  • 50 Shock, Multiple Organ Dysfunction Syndrome, and Burns in Children
  • Shock and Multiple Organ Dysfunction Syndrome
  • Burns
  • Summary Review
  • Key Terms
  • References
  • Glossary
  • A
  • B
  • C
  • D
  • E
  • F
  • G
  • H
  • I
  • J
  • K
  • L
  • M
  • N
  • O
  • P
  • Q
  • R
  • S
  • T
  • U
  • V
  • W
  • X
  • Z
  • Index
  • Endsheet

Product details

  • No. of pages: 1720
  • Language: English
  • Copyright: © Mosby 2017
  • Published: December 27, 2016
  • Imprint: Mosby
  • Paperback ISBN: 9780323639507
  • eBook ISBN: 9780323413206

About the Authors

Kathryn McCance

Affiliations and Expertise

Professor, College of Nursing, University of Utah, Salt Lake City, UT

Sue Huether

Affiliations and Expertise

Professor Emeritus, College of Nursing, University of Utah, Salt Lake City, UT

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